Enzymatic Polymerization of an Ibuprofen-Containing Monomer and Subsequent Drug Release

Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-cyclodextrin complex.

Mixtures containing ibuprofen (IB) complexed with β-cyclodextrin (βCD) obtained by two complexation methods [suspension/solution (with water removed by air stream, spray- and freeze-drying) and kneading technique] were processed into pharmaceutical dosage forms (minitablets and capsules). Powders (IB, βCD and IBβCD) were characterized for moisture content, densities (true and bulk), angle of re...

Study of Release Kinetics and Statistical Optimization of Slow Release Effervescent Tablet Containing Ibuprofen

2 The work investigates the formulation development, evaluation and optimization of ibuprofen effervescent tablet using 3 factorial designs. The effect of variables viz. xanthan gum and sodium bicarbonate on drug release and hardness of ibuprofen effervescent tablets were analyzed and optimized. The optimized formulation showed the ibuprofen release in sustained manner over a period of 6h. The ...

Preparative synthesis of Poly[(R)-3-hydroxybutyrate] monomer for enzymatic cell-free polymerization

INTRODUCTION Polyhydroxyalkanoates (PHAs) are produced as a carbon and energy storage material in various bacteria, and have received much attention as biodegradable and biocompatible plastics. PHAs can be produced from renewable carbon sources such as sugars, fatty acids and plant oils by fermentation.1 Poly[(R)-3-hydroxybutyrate], P(3HB), is the most widely studied and best characterized PHA....

A selectivity-driven supramolecular polymerization of an AB monomer.

Synthesis, characterization and polymerization of a novel acrylate monomer containing both 4H-pyran-4-one and 1,2,3-triazole moiety and evaluation of their antibacterial activity

A novel acrylate monomer containing 4H-pyran-4-one and 1,2,3-triazole ring, {1-[4-(4-oxo-6-phenyl-4H-pyran-2-yl)benzyl]-1,2,3-triazol-4-yl}methyl acrylate was synthesized by the reaction of 2-{4-[(4-(hydroxymethyl)-1,2,3-triazol-1-yl)methyl]phenyl}-6-phenyl-4H-pyran-4-one with acryloyl chloride in the presence of triethylamine. The structure of the acrylate monomer was established on the basis ...